教师名录

严亚贤

职称:教授

研究方向:分子病原学

电话:021-34206003

邮箱:yanyaxian@sjtu.edu.cn

个人简历:

严亚贤,博士,上海交通大学长聘教授,博士生导师。多年来一直从事微生物学相关的教学和科研工作。主持国家863项目、重点研发课题、国家自然科学基金项目、上海市级科研项目等,发表科研论文100多篇,其中3篇为ESI高被引论文,1篇为ESI热点论文。科研成果获上海市科技进步三等奖(主持);参与的项目获教育部科学技术进步奖二等奖;获农业部科学技术进步一等奖;获江苏省科学技术进步奖三等奖等。曾获上海交通大学优秀教师、三八红旗手、教书育人三等奖等。

 

教育工作经历:

毕业于南京农业大学,获预防兽医学博士学位。曾到英国利物浦大学进行访学和合作研究。1999年9月起一直在上海交通大学农业于生物学院工作。

 

主要研究内容:

主要研究方向为噬菌体与宿主细菌的互作机制、动物病毒免疫逃逸机制及防控、真菌毒素毒理机制与检测技术等。针对耐药细菌,解析宿主细菌对噬菌体的耐受机制、及噬菌体突破耐受细菌不断演化的机制,进一步研发高效噬菌体抗菌制剂。针对动物病毒,特别是动物冠状病毒,解析病毒逃避宿主免疫的机制,研发新型疫苗等。课题组还以小分子物质特别是真菌毒素为靶标对象,研究真菌毒素引致细胞毒性的分子信号调控路径。利用量子点和基团修饰,结合核酸适配体,研发具有超灵敏特征的定性和定量快速多重免疫分析方法。

 

主要承担项目:

  1. 国家重点研发课题:人工噬菌体与宿主的互作及临床前应用评价,2019YFA0904004。
  2. 国家自然科学基金:大肠杆菌硫氧还蛋白DsbA调控T1样噬菌体复制的分子基础与作用机制,32072822。
  3. 国家自然科学基金:密度感应信号分子AI-2激活大肠杆菌CRISPR-Cas适应性免疫的分子基础与调控机制,31772744。
  4. 国家自然科学基金:Stx噬菌体突破宿主菌CRISPR免疫系统导致多重溶原的分子互作机制,31272580。
  5. 上海市科技兴农技术创新项目:猪丁型冠状病毒高效灭活疫苗的创制,2021-02-08-00-12-F00773。
  6. 上海市科技兴农推广项目:新发猪Delta冠状病毒与猪流行性腹泻病毒嵌合 VLP粘膜疫苗的研制,编号:沪农科推字(2017)第1-10号。
  7. 国家高技术研究发展计划(863项目)课题:重要真菌毒素快速免疫检测技术,编号:2007AA10Z424。
  8. 国家自然科学基金:模拟真菌毒素表位的嵌合核酸适配子的构建及无毒、环保真菌毒素检测体系的建立,31571932。
  9. 上海市“科技创新行动计划” 项目:小麦中多种真菌毒素快速定量检测技术及试剂盒的研发,编号:17391901400。
  10. 上海市科技兴农推广项目:集约化奶牛场微生态制剂环境消毒模式的探索及应用示范,沪农科推字(2019)第2-2-19号。

 

主要研究成果:

论文:

  1. Yuqiang Cheng, Wenxian Zhu, Chan Ding, Qiaona Niu, Hengan Wang, Yaxian Yan*, Jianhe Sun*. IRF7 Is Involved in Both STING and MAVS Mediating IFN-beta Signaling in IRF3-Lacking Chickens[J]. Journal of Immunology. 2019. 203(7): 1930-1942. Q1,TOP.
  2. Likai Ji, Qianqian Liu, Na Wang, Yan Wang, Jianhe Sun, Yaxian Yan, Porcine dsRNA-binding protein Staufen1 facilitate dsRNA-RIG-I/MDA5 binding to activate the antiviral innate immunity response. Veterinary Microbiology. 2022, 272: 109515. TOP, Q1.
  3. Likai Ji, Shasha Li, Wenxian Zhu, Jingjiao Ma, Jianhe 8Sun, Hengan Wang, Yaxian Yan*. Porcine deltacoronavirus nucleocapsid protein suppressed IFN-beta production by interfering porcine RIG-I dsRNA-binding and K63-linked polyubiquitination [J]. Frontiers in Immunology. 2019, 10: 1024.  Q2, TOP.
  4. Likai Ji, Na Wang, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan*. Porcine deltacoronavirus nucleocapsid protein species-specifically suppressed IRF7-induced type I interferon production via ubiquitin-proteasomal degradation pathway [J]. Veterinary Microbiology. 2020, 250: 108853. Q1 ,TOP.
  5. Yuqiang Cheng, Yunxia Liu, Shuduan Shi, Qiaona Niu, Wenxian Zhu, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan*, Jianhe Sun*. Functional Characterization of Duck STING in IFN-beta Induction and Anti-H9N2 Avian Influenza Viruses Infections[J]. Frontiers in Immunology. 2019. 10: 2224.  Q2, TOP.
  6. Wang Z, Kong L, Liu Y, Fu Q, Cui Z, Wang J, Ma J, Wang H, Yan Y, Sun J. A phage lysin fused to a cell-penetrating peptide kills intracellular methicillin-resistant Staphylococcus aureus in keratinocytes and has potential as a treatment for skin infections in mice. Appl Environ Microbiol, 2018, 84: e00380-18.
  7. Denghui Yang, Zhaofei Wang, Jingjiao Ma, Qiang Fu, Lifei Wu, Hengan Wang, Shaohui Wang, Yaxian Yan*, Jianhe Sun*. Glycine Cleavage System and cAMP Receptor Protein Co-Regulate CRISPR/cas3 Expression to Resist Bacteriophage[J]. Viruses-Basel. 2020, 12: 90. Q2.
  8. Qiang Fu ,Shiyu Li ,Zhaofei Wang ,Wenya Shan,Jingjiao Ma,Yuqiang Cheng,Hengan Wang,Yaxian Yan* and Jianhe Sun*. H-NS Mutation-Mediated CRISPR-Cas Activation Inhibits Phage Release and Toxin Production of Escherichia coli Stx2 Phage Lysogen[J]. Frontiers in Microbiology. 2017, 8: 652-663. Q2.
  9. Zhaofei Wang, Yibing Xue, Ya Gao, Yuanping Liu, Mengting Guo, Xinwei Zou, Yuqiang Cheng, Jingjiao Ma, Hengan Wang, Jianhe Sun, Yaxian Yan*. Phage vB_PaeS-PAJD-1 rescues murine mastitis infected with multidrug-resistant Pseudomonas aeruginosa [J]. Frontiers in Cellular and Infection Microbiology. 2021, 11: 689770. Q2.
  10. Zhaofei Wang, Panpan Zheng,Wenhui Ji, Qiang Fu, HenganWang, Yaxian Yan* and Jianhe Sun*. SLPW: Avirulent Bacteriophage Targeting Methicillin-Resistant Staphylococcus aureus In vitro and In vivo[J]. Frontiers in Microbiology. 2016, 7: 934. Q2, TOP.
  11. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Zhaofei Wang, Yaxian Yan. Overview—gold nanoparticles-based sensitive nanosensors in mycotoxins detection. Critical Reviews in Food Science and Nutrition, 2022, DOI: 10.1080/10408398.2022.2095973
  12. Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Yan.  DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells. Food and Chemical Toxicology, 2022, 171, 113531, TOP.
  13. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan*. The toxicity mechanisms of DON to humans and animals and potential biological treatment strategies. Critical reviews in food science and nutrition,2021, DOI: 10.1080/10408398.2021.1954598. Q1, TOP.
  14. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan*. One-step rapid detection of fumonisin B1, dexyonivalenol and zearalenone in grains [J]. Food Control. 2020, 117: 107107. Q1, TOP.
  15. Silu Hou, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Jianhe Sun, Yaxian Yan. Quantum dot nanobead-based fluorescent immunochromatographic assay for simultaneous quantitative detection of fumonisin B1, dexyonivalenol, and zearalenone in grains [J]. Food Control. 2020, 117: 107331. Q1, TOP.

专著:

  1. 严亚贤参编《兽医微生物学》,陆承平,刘永杰主编。中国农业出版社,2021年8月,普通高等教育农业农村部“十三五”规划教材
  2. 作为副主译,编译《兽医微生物学及所致传染病》(第2版),陈继明等主译,中国农业出版社,2019.
  3. 作为编委,编著《噬菌体学:从理论到实践》,胡福泉,童贻刚主编,科技出版社,2021.

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