教师名录

孙     涛

职       称: 研究员/博士生导师

所属学科: 动物科学

研究方向动物病毒学;动物免疫学

电      话:021-34207240

电子信箱tao.sun@sjtu.edu.cn 

联系地址: 上海市闵行区东川路800号,必威3-401室,邮编:200240                                         

 

主要教育经历:

 2005年获上海交通大学生物化学与分子生物学专业博士学位;

 2005.12-2007.4,美国纽约大学Mount Sinai 医学院博士后;

 2007.4-2009.3 月,美国迈阿密大学医学院博士后;

 2014.1-2015.1,英国“动物健康与兽医研究所”(AHVLA)病毒学实验室访问学者。

 

教学工作:

主讲本科平台课“普通生物学”; 研究生“现代免疫学”等课程。

 

科学研究

长期从事动物病毒学研究工作,包括猪流行性腹泻病毒、水泡性口炎病毒及口蹄疫病毒等,主要内容包括:①病毒与家畜动物宿主互作及对致病性的影响;②新型病毒疫苗载体的构建和应用;③新型天然产物疫苗佐剂的研制和免疫作用机理研究。

 

荣誉奖励

2016年入选上海市闵行区领军人才。

 

主要科研项目

1.以假型化VSV为载体研制新冠病毒δ变异株应急免疫疫苗. 上海市2022年度“科技创新行动计划”生物医药科技支撑专项项目(22S11902200). 起止年限:2022.4-2025.3. 主持.

2. SARS-CoV-2病毒特异性中和抗体高通量检测和筛选方法的建立.教育部细胞工程与抗体中心开放课题(19X110020009-003).起止年限:2020.7-2022.6. 主持.

3. 进口蜂蜜和鱼粉中抗生素抗性基因的高通量检测及其风险评估. 上海市科技兴农重点攻关项目(2018-02-08-00-10-F01548). 起止年限:2018.7- 2021.7. 主要参与人.

5. 猪流行性腹泻病毒新发病毒株的致病性研究. 2016年上海市闵行区领军人才建设专项资金资助. 主持

6. 用于筛查水泡性口炎病毒感染家畜的诊断试剂盒研制和临床应用. 上海市闵行区产学研合作计划项目( 2016MH250) . 起止年限:2016.9- 2018.6. 主持

7. 新型猪流行性腹泻病毒(PEDV) 应急免疫疫苗研制。上海市科委2015年度“科技创新行动计划”医学和农业领域科技支撑项目(15391901600)。起止年限:2015.7.1-2017.12.30,主持

8. 水泡性口炎病毒基质蛋白(M)对猪天然免疫应答的抑制作用研究。国家自然科学基金面上项目(31272562),起止年限:2013.01-2016.12,主持

9.环境因子作用于视网膜上皮细胞后相关基因表达特征谱。国家重点基础研究发展计划(973)子课题。起止年限:2012.1-2014.1.子课题主持人

10. 条件复制型水泡性口炎病毒载体的研制. 教育部留学回国人员科研启动基金(Z102712), 起止年限:2011.1-2013.1,主持

11. 新型减毒水泡性口炎病毒载体的研制. 上海市兽医生物技术重点实验室开放课题(KLAB201003), 起止年限:2010.6-2012.6, 主持

12.大豆皂苷及其衍生物免疫佐剂和溶血活性的定量构效关系研究,国家自然科学基金面上项目(31071630),起止年限:2011.1-2013.12,主要完成人。


主要科研成果

 (1) 科研论文: *为通讯作者

1. Tang H, Ke Y, Wang L, Wu M*, Sun T*, Zhu J*. Recombinant Decoy Exhibits Broad Protection against Omicron and Resistance Potential to Future Variants. Pharmaceuticals. 2022, 15, 1002. https://doi.org/10.3390/ph15081002

2. Jinghui Yao , Jing Gao, Jianming Guo , Hengan Wang , En Zhang, Yingzheng Lin , Zhifei Chen , Shuqing Li *Sun Tao*. Characterization of Bacteria and Antibiotic Resistance in Commercially Produced Cheeses Sold in China. J Food Prot. 2022 ,85(3):484-493.

3. Yong Ke, Dayi Yu, Fanqin Zhang, Jin Gao, Xiaoyu Wang, Xinkui Fang, Hengan Wang, Tao sun*. Recombinant vesicular stomatitis virus expressing the spike protein of genotype 2b porcine epidemic diarrhea virus: a platform for vaccine development against emerging epidemic isolates. Virology. 2019,533:77-85

4. Guoyan Sun, Xinkui Fang, Hao Wu, Xinchu Zhou, Yong Ke, Tao Sun*. Porcine monocyte-derived dendritic cells can be differentially activated by vesicular stomatitis virus and its matrix protein mutants. Veterinary Microbiology. 2018, 219(6): 30-39

5. Li W, Jiang Y, Sun T, Yao X, Sun X. Supplementation of procyanidins B2 attenuates photooxidation-induced apoptosis in ARPE-19 cells. Int J Food SciNutr.2016 ,67(6):650-9

6. Xinkui Fang, Bing Qi, Yufang Ma, Xinchu Zhou , Shikuan Zhang,  Tao Sun*.Assessment of a Novel Recombinant Vesicular Stomatitis Virus with Triple Mutations in its Matrix Protein as a Vaccine for Pigs. Vaccine. 2015, 33(46): 6268–6276

7. Liu S, Zhao L, Zhai Z, Zhao W, Ding J, Dai R, Sun T*, Meng H*. Porcine Epidemic Diarrhea Virus Infection Induced the Unbalance of Gut Microbiota in Piglets. Curr Microbiol. 2015,71(6):643–649

8. Tao Sun, Xinbin Yan, Wenxiu Guo, Dayun Zhao. Evaluation of cytotoxicity and immune modulatory activities of soyasaponin Ab: An in vitro and in vivo study. Phytomedicine. 2014,21(13): 1759–1766.

9. Zhao Zhao , Tao Sun , Yun Jiang , LijiangWu, Xiangzhong Cai , Xiaodong Sun , Xiangjun Sun . Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols. Food and Chemical Toxicology 74 (2014) 216–224. (first author with equal contribution).

10. Xinkui Fang, Shikuan Zhang, Xiaodong Sun, Jinjin Li, Tao Sun*.  Evaluation of attenuated VSVs with mutated M or/and G proteins as vaccine vectors. Vaccine. 2012,30(7):1313-1321

11. T. Sun, Q.Y. Chen, L.J. Wu, X.M. Yao, X.J. Sun. Antitumor and antimetastatic activities of grape skin polyphenols in a murine model of breast cancer. Food and Chemical Toxicology, 2012, 50 (10):3462–3467

12. Fang Xin-kui , Xin Wang, Tao Sun*. Construction and application of vesicular stomatitis virus retargeting at adult T cell leukemia. Progress in Biochemistry and Biophysics,2011,38(3):218-226

13. Fang Xin-Kui, Huang Dan-Feng, Wang Zhao-Xia, Wan Chun-Ling, Sun Tao, Xu Wang-Jie, Liu Chun-Yan, Zhou Pei, Qiao Zhong-Dong. Identification of the proteins related to cytochrome P450 induced by fenvalerate in a Trichoplusia ni cell line. Cell Biology and Toxicology. 2007, 23:445-457

14. Tao Sun, Lu Ping, Fang Xinkui. Expression and Application of the Recombinant Non-Structural Protein of FMDV. Journal of Shanghai Jiaotong University(Science).Vol.E-10,Sup.1,2005:61-64

15.Tao Sun, Lu Ping, Wang Xin. Localization of infection-related epitopes on non-structural protein 3ABC of foot-and-mouth disease virus and the application of tandem epitopes. Journal of Virological Methods. 2004,119:79-86

16. Tao Sun, Lu Ping, Wang Xin. An applicable method for mapping epitopes on viral protein. Progress in Biochemistry and Biophysics. 2004(3):255-259

17. Cao ShengFeng, Ping Lu, Tao Sun, Xing Wang and Wang Guo F eng. Construction, Expression, Purification, Refold and Activity assay of a specific scFv fragment against Foot and Mouth disease virus. Veterinary Research Communication. 2003,27:243-256

(2) 发明专利

1. 孙涛,方心葵,柯勇. 利用重组水泡性口炎病毒(VSV)构建预防猪流行性腹泻病毒(PEDV)疫苗. 专利授权号:ZL201810412129.1

2. 感染VSV的动物体内M蛋白抗体的ELISA检测试剂盒及其检测方法. 孙涛,方心葵. 专利授权号:ZL 201310009365.6

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